Long-term effects of the glucocorticoid receptor modulator cort 113176 in murine motoneuron degeneration.

Long-term effects of the glucocorticoid receptor modulator cort 113176 in murine motoneuron degeneration.

The Wobbler rat spinal cord motoneurons showed vacuolization especially, glial reaction, inflammation and abnormal glutamatergic parameters. Wobblers also showed a deficit of motor performance. This condition resembles amyotrophic lateral sclerosis (ALS). Wobbler mice also showed higher levels of corticosterone in the blood, adrenal and brain plus adrenal hypertrophy, suggesting that increased glucocorticoid prime chronic spinal cord nerve inflammation.

Therefore, we analyzed if treatment Wobbler mice with the glucocorticoid receptor (GR) antagonist reduced CORT113176 mentioned disorders. 30 mg / kg CORT113176 administered daily for 3 weeks reduced motoneuron vacuolation, decrease in astro and microgliosis, lowers inflammatory mediators group of high mobility box 1 protein (HMGB1), pulses like receptor 4, myeloid differentiation primary response 88 (MyD88), p50 subunit factor nuclear kappa B (NF), tumor necrosis factor (TNF) receptor, and interleukin 18 (IL18) compared with untreated Wobblers. CORT113176 improve survival signal pAkt (serine-threonine kinases) and a decrease in phosphorylated death signal Trash-N-terminal kinase (pJNK), symptoms of anti-apoptotic.

There was a moderate positive effect on glutamine synthase and astrocyte glutamate transporters, showed a decrease in glutamate excitotoxicity. In these pre-clinical studies, Wobblers receive CORT113176 show increased resistance to fatigue in the rota rod test and atrophy of the lower front leg in Week 2- 3. Therefore, the long-term treatment with attenuated CORT113176 degeneration and inflammation, improve motor performance and decrease foot deformities. Antagonism of GR may be a potential therapeutic value for neurodegenerative diseases.

Long-term effects of the glucocorticoid receptor modulator cort 113176 in murine motoneuron degeneration.
Long-term effects of the glucocorticoid receptor modulator cort 113176 in murine motoneuron degeneration.

resistin expression in human monocytes is controlled by two SNPs associated promoter binding mediation NFkB p50 / p50 and C-methylation.

Resistin is a key cytokine associated with metabolic and inflammatory diseases. Especially in East Asian populations, the level of expression is strongly influenced by genetic polymorphisms. The mechanism and functional implications of this genetic control remains unknown. By using the test reporter, EMSA, the study of inhibition, sequencing of bisulfite, CHIP-Seq and gene-editing we showed that the homodimer p50 / p50 is known to act as a repressor for a number of genes of pro-inflammation plays a central role in the genetic regulation of resistin in monocytes along with promoter methylation.

RETN common haplotype in the p50 / p50 offset constitutive expression by binding to the promoter. In a variant haplotypes Asia but this interaction is disrupted by the A allele of rs3219175. SNP is a very close relationship with rs34861192, a SNP CpG, located 280 bp upstream of the supply site C-allele-specific methylation.

rs34861192 lies in the region of 100 bp was found methylated haplotype similarities but not in Asia, so that the latter have a higher basal expression, which also associates with increased histone acetylation (H3K27ac). genotype associations in cohort data from 200 East Asians revealed a significant association between this haplotype and plasma levels of factors such as TGF-b, S100B, sRAGE and IL-8 as well as the number of myeloid DC.

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Thus, a common haplotype RETN tightly regulated by epigenetic mechanisms associated with p50 / p50-binding. This control is missing in the Asian haplotypes, which may have evolved to balance antagonistic effects on the protection RETN pathogen induction vs metabolism and inflammatory diseases.

Sarah

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