The Wobbler rat spinal cord motoneurons showed vacuolization especially, glial reaction, inflammation and abnormal glutamatergic parameters. Wobblers also showed a deficit of motor performance. This condition resembles amyotrophic lateral sclerosis (ALS). Wobbler mice also showed higher levels of corticosterone in the blood, adrenal and brain plus adrenal hypertrophy, suggesting that increased glucocorticoid prime chronic spinal cord nerve inflammation.

Therefore, we analyzed if treatment Wobbler mice with the glucocorticoid receptor (GR) antagonist reduced CORT113176 mentioned disorders. 30 mg / kg CORT113176 administered daily for 3 weeks reduced motoneuron vacuolation, decrease in astro and microgliosis, lowers inflammatory mediators group of high mobility box 1 protein (HMGB1), pulses like receptor 4, myeloid differentiation primary response 88 (MyD88), p50 subunit factor nuclear kappa B (NF), tumor necrosis factor (TNF) receptor, and interleukin 18 (IL18) compared with untreated Wobblers. CORT113176 improve survival signal pAkt (serine-threonine kinases) and a decrease in phosphorylated death signal Trash-N-terminal kinase (pJNK), symptoms of anti-apoptotic.

There was a moderate positive effect on glutamine synthase and astrocyte glutamate transporters, showed a decrease in glutamate excitotoxicity. In these pre-clinical studies, Wobblers receive CORT113176 show increased resistance to fatigue in the rota rod test and atrophy of the lower front leg in Week 2- 3. Therefore, the long-term treatment with attenuated CORT113176 degeneration and inflammation, improve motor performance and decrease foot deformities. Antagonism of GR may be a potential therapeutic value for neurodegenerative diseases.

resistin expression in human monocytes is controlled by two SNPs associated promoter binding mediation NFkB p50 / p50 and C-methylation.

Resistin is a key cytokine associated with metabolic and inflammatory diseases. Especially in East Asian populations, the level of expression is strongly influenced by genetic polymorphisms. The mechanism and functional implications of this genetic control remains unknown. By using the test reporter, EMSA, the study of inhibition, sequencing of bisulfite, CHIP-Seq and gene-editing we showed that the homodimer p50 / p50 is known to act as a repressor for a number of genes of pro-inflammation plays a central role in the genetic regulation of resistin in monocytes along with promoter methylation.

RETN common haplotype in the p50 / p50 offset constitutive expression by binding to the promoter. In a variant haplotypes Asia but this interaction is disrupted by the A allele of rs3219175. SNP is a very close relationship with rs34861192, a SNP CpG, located 280 bp upstream of the supply site C-allele-specific methylation.

rs34861192 lies in the region of 100 bp was found methylated haplotype similarities but not in Asia, so that the latter have a higher basal expression, which also associates with increased histone acetylation (H3K27ac). genotype associations in cohort data from 200 East Asians revealed a significant association between this haplotype and plasma levels of factors such as TGF-b, S100B, sRAGE and IL-8 as well as the number of myeloid DC.

NF- kappaB p105/p50 Antibody
ABF6217	Nova Lifetech	100ug	EUR 325

NF kappaB p105/p50 Antibody
MBS5314739-01mL	MyBiosource	0.1mL	EUR 535

NF kappaB p105/p50 Antibody
MBS5314739-5x01mL	MyBiosource	5x0.1mL	EUR 2270

NF kappaB p105/p50 Antibody
MBS5314740-01mL	MyBiosource	0.1mL	EUR 470

NF kappaB p105/p50 Antibody
MBS5314740-5x01mL	MyBiosource	5x0.1mL	EUR 1955

NF kappaB p105/p50 Antibody
MBS9631424-1mg	MyBiosource	1mg	EUR 375

NF kappaB p105/p50 Antibody
MBS9631424-5x1mg	MyBiosource	5x1mg	EUR 1545

NF kappaB p105/p50 Antibody
MBS9629026-01mL	MyBiosource	0.1mL	EUR 260

NF kappaB p105/p50 Antibody
MBS9629026-02mL	MyBiosource	0.2mL	EUR 305

NF kappaB p105/p50 Antibody
MBS9629026-5x02mL	MyBiosource	5x0.2mL	EUR 1220

Phospho- NF- kappaB p105/p50 (Ser927) Antibody
ABF3217	Nova Lifetech	100ug	EUR 325

Phospho- NF- kappaB p105/p50 (Ser932) Antibody
ABF3218	Nova Lifetech	100ug	EUR 325

Phospho- NF- kappaB p105/p50 (Ser337) Antibody
ABF3219	Nova Lifetech	100ug	EUR 325

Phospho- NF- kappaB p105/p50 (Ser893) Antibody
ABF3220	Nova Lifetech	100ug	EUR 325

Phospho- NF- kappaB p105/p50 (Ser907) Antibody
ABF3221	Nova Lifetech	100ug	EUR 325

Phospho-NF- kappaB p105/p50 (Ser927) Antibody
E18-3217-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser927) Antibody
E18-3217-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser932) Antibody
E18-3218-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser932) Antibody
E18-3218-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser337) Antibody
E18-3219-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser337) Antibody
E18-3219-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser893) Antibody
E18-3220-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser893) Antibody
E18-3220-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser907) Antibody
E18-3221-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

Phospho-NF- kappaB p105/p50 (Ser907) Antibody
E18-3221-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

Phospho-NF kappaB p105/p50 (Ser927) Antibody
AF3217	Affbiotech	200ul	EUR 420

Phospho-NF kappaB p105/p50 (Ser927) Antibody
AF3217-100ul	Affinity Biosciences	100ul	EUR 280

Phospho-NF kappaB p105/p50 (Ser927) Antibody
AF3217-200ul	Affinity Biosciences	200ul	EUR 350

Phospho-NF kappaB p105/p50 (Ser932) Antibody
AF3218	Affbiotech	200ul	EUR 420

Phospho-NF kappaB p105/p50 (Ser932) Antibody
AF3218-100ul	Affinity Biosciences	100ul	EUR 280

Phospho-NF kappaB p105/p50 (Ser932) Antibody
AF3218-200ul	Affinity Biosciences	200ul	EUR 350

Phospho-NF kappaB p105/p50 (Ser337) Antibody
AF3219	Affbiotech	200ul	EUR 420

Phospho-NF kappaB p105/p50 (Ser337) Antibody
AF3219-100ul	Affinity Biosciences	100ul	EUR 280

Phospho-NF kappaB p105/p50 (Ser337) Antibody
AF3219-200ul	Affinity Biosciences	200ul	EUR 350

Phospho-NF kappaB p105/p50 (Ser893) Antibody
AF3220	Affbiotech	200ul	EUR 420

Phospho-NF kappaB p105/p50 (Ser893) Antibody
AF3220-100ul	Affinity Biosciences	100ul	EUR 280

Phospho-NF kappaB p105/p50 (Ser893) Antibody
AF3220-200ul	Affinity Biosciences	200ul	EUR 350

Phospho-NF kappaB p105/p50 (Ser907) Antibody
AF3221	Affbiotech	200ul	EUR 420

Phospho-NF kappaB p105/p50 (Ser907) Antibody
AF3221-100ul	Affinity Biosciences	100ul	EUR 280

Phospho-NF kappaB p105/p50 (Ser907) Antibody
AF3221-200ul	Affinity Biosciences	200ul	EUR 350

Phospho-NF kappaB p105/p50 (Ser903) Antibody
AF8013	Affbiotech	200ul	EUR 540

Phospho-NF kappaB p105/p50 (Ser903) Antibody
AF8013-100ul	Affinity Biosciences	100ul	EUR 350

Phospho-NF kappaB p105/p50 (Ser903) Antibody
AF8013-200ul	Affinity Biosciences	200ul	EUR 450

Phospho-NF kappaB p105/p50 (Ser923) Antibody
AF8014	Affbiotech	200ul	EUR 540

Phospho-NF kappaB p105/p50 (Ser923) Antibody
AF8014-100ul	Affinity Biosciences	100ul	EUR 350

Phospho-NF kappaB p105/p50 (Ser923) Antibody
AF8014-200ul	Affinity Biosciences	200ul	EUR 450

Phospho-NF kappaB p105/p50 (Ser903) Antibody
MBS9614014-005mL	MyBiosource	0.05mL	EUR 245

Phospho-NF kappaB p105/p50 (Ser903) Antibody
MBS9614014-01mL	MyBiosource	0.1mL	EUR 310

Phospho-NF kappaB p105/p50 (Ser903) Antibody
MBS9614014-02mL	MyBiosource	0.2mL	EUR 370

Phospho-NF kappaB p105/p50 (Ser903) Antibody
MBS9614014-5x02mL	MyBiosource	5x0.2mL	EUR 1605

Phospho-NF kappaB p105/p50 (Ser923) Antibody
MBS9614015-005mL	MyBiosource	0.05mL	EUR 245

Phospho-NF kappaB p105/p50 (Ser923) Antibody
MBS9614015-01mL	MyBiosource	0.1mL	EUR 310

Phospho-NF kappaB p105/p50 (Ser923) Antibody
MBS9614015-02mL	MyBiosource	0.2mL	EUR 370

Phospho-NF kappaB p105/p50 (Ser923) Antibody
MBS9614015-5x02mL	MyBiosource	5x0.2mL	EUR 1605

Phospho-NF kappaB p105/p50 (Ser927) Antibody
MBS9600988-01mL	MyBiosource	0.1mL	EUR 260

Phospho-NF kappaB p105/p50 (Ser927) Antibody
MBS9600988-02mL	MyBiosource	0.2mL	EUR 305

Phospho-NF kappaB p105/p50 (Ser927) Antibody
MBS9600988-5x02mL	MyBiosource	5x0.2mL	EUR 1220

Phospho-NF kappaB p105/p50 (Ser932) Antibody
MBS9600989-01mL	MyBiosource	0.1mL	EUR 260

Phospho-NF kappaB p105/p50 (Ser932) Antibody
MBS9600989-02mL	MyBiosource	0.2mL	EUR 305

Phospho-NF kappaB p105/p50 (Ser932) Antibody
MBS9600989-5x02mL	MyBiosource	5x0.2mL	EUR 1220

Phospho-NF kappaB p105/p50 (Ser337) Antibody
MBS9600990-01mL	MyBiosource	0.1mL	EUR 260

Phospho-NF kappaB p105/p50 (Ser337) Antibody
MBS9600990-02mL	MyBiosource	0.2mL	EUR 305

Phospho-NF kappaB p105/p50 (Ser337) Antibody
MBS9600990-5x02mL	MyBiosource	5x0.2mL	EUR 1220

Phospho-NF kappaB p105/p50 (Ser893) Antibody
MBS9600991-01mL	MyBiosource	0.1mL	EUR 260

Phospho-NF kappaB p105/p50 (Ser893) Antibody
MBS9600991-02mL	MyBiosource	0.2mL	EUR 305

Phospho-NF kappaB p105/p50 (Ser893) Antibody
MBS9600991-5x02mL	MyBiosource	5x0.2mL	EUR 1220

Phospho-NF kappaB p105/p50 (Ser907) Antibody
MBS9600992-01mL	MyBiosource	0.1mL	EUR 260

Phospho-NF kappaB p105/p50 (Ser907) Antibody
MBS9600992-02mL	MyBiosource	0.2mL	EUR 305

Phospho-NF kappaB p105/p50 (Ser907) Antibody
MBS9600992-5x02mL	MyBiosource	5x0.2mL	EUR 1220

NF kappaB p105 antibody
70R-51601	Fitzgerald	100 ul	EUR 286
Description: Purified Polyclonal NF kappaB p105 antibody

NF kappaB p105 antibody
70R-51602	Fitzgerald	100 ul	EUR 242
Description: Purified Polyclonal NF kappaB p105 antibody

NF kappaB p105 antibody
70R-50117	Fitzgerald	100 ul	EUR 286
Description: Purified Polyclonal NF kappaB p105 antibody

NF kappaB p105 antibody
70R-50118	Fitzgerald	100 ul	EUR 242
Description: Purified Polyclonal NF kappaB p105 antibody

NF kappaB p105 Antibody
MBS5314737-01mL	MyBiosource	0.1mL	EUR 535

NF kappaB p105 Antibody
MBS5314737-5x01mL	MyBiosource	5x0.1mL	EUR 2270

NF kappaB p105 Antibody
MBS5314738-01mL	MyBiosource	0.1mL	EUR 470

NF kappaB p105 Antibody
MBS5314738-5x01mL	MyBiosource	5x0.1mL	EUR 1955

NF kappaB p105 Antibody
MBS5316217-01mL	MyBiosource	0.1mL	EUR 535

NF kappaB p105 Antibody
MBS5316217-5x01mL	MyBiosource	5x0.1mL	EUR 2270

NF kappaB p105 Antibody
MBS5316218-01mL	MyBiosource	0.1mL	EUR 470

NF kappaB p105 Antibody
MBS5316218-5x01mL	MyBiosource	5x0.1mL	EUR 1955

AFfirm™ NF kappaB p105/p50 Mouse Monoclonal Antibody
BF8151	Affinity Biosciences	100ul	EUR 280
Description: Human,Mouse,Rat

AFfirm™ NF kappaB p105/p50 Mouse Monoclonal Antibody
BF8151-100ul	Affinity Biosciences	100ul	EUR 280

AFfirm™ NF kappaB p105/p50 Mouse Monoclonal Antibody
BF8151-200ul	Affinity Biosciences	200ul	EUR 350

NF kappaB p105/p50 Blocking Peptide
MBS9617362-1mg	MyBiosource	1mg	EUR 380

NF kappaB p105/p50 Blocking Peptide
MBS9617362-5x1mg	MyBiosource	5x1mg	EUR 1650

Rabbit Polyclonal NF- kappaB p105/p50 (Ser337) Antibody (Phospho-specific)
TA325716	Origene Technologies GmbH	100 µl	Ask for price

Rabbit Polyclonal NF- kappaB p105/p50 (Ser893) Antibody (Phospho-specific)
TA325717	Origene Technologies GmbH	100 µl	Ask for price

Rabbit Polyclonal NF- kappaB p105/p50 (Ser907) Antibody (Phospho-specific)
TA325718	Origene Technologies GmbH	100 µl	Ask for price

Rabbit Polyclonal NF- kappaB p105/p50 (Ser927) Antibody (Phospho-specific)
TA325719	Origene Technologies GmbH	100 µl	Ask for price

Rabbit Polyclonal NF- kappaB p105/p50 (Ser932) Antibody (Phospho-specific)
TA325720	Origene Technologies GmbH	100 µl	Ask for price

Phospho-NF kappaB p105/p50 (Ser927) Blocking Peptide
AF3217-BP	Affbiotech	1mg	EUR 234

Phospho-NF kappaB p105/p50 (Ser932) Blocking Peptide
AF3218-BP	Affbiotech	1mg	EUR 234

Phospho-NF kappaB p105/p50 (Ser337) Blocking Peptide
AF3219-BP	Affbiotech	1mg	EUR 234

Phospho-NF kappaB p105/p50 (Ser893) Blocking Peptide
AF3220-BP	Affbiotech	1mg	EUR 234

Phospho-NF kappaB p105/p50 (Ser907) Blocking Peptide
AF3221-BP	Affbiotech	1mg	EUR 234

Phospho-NF kappaB p105/p50 (Ser927) Blocking Peptide
MBS9615571-1mg	MyBiosource	1mg	EUR 380

Phospho-NF kappaB p105/p50 (Ser927) Blocking Peptide
MBS9615571-5x1mg	MyBiosource	5x1mg	EUR 1650

Phospho-NF kappaB p105/p50 (Ser932) Blocking Peptide
MBS9615572-1mg	MyBiosource	1mg	EUR 380

Phospho-NF kappaB p105/p50 (Ser932) Blocking Peptide
MBS9615572-5x1mg	MyBiosource	5x1mg	EUR 1650

Phospho-NF kappaB p105/p50 (Ser337) Blocking Peptide
MBS9615573-1mg	MyBiosource	1mg	EUR 380

Phospho-NF kappaB p105/p50 (Ser337) Blocking Peptide
MBS9615573-5x1mg	MyBiosource	5x1mg	EUR 1650

Phospho-NF kappaB p105/p50 (Ser893) Blocking Peptide
MBS9615574-1mg	MyBiosource	1mg	EUR 380

Phospho-NF kappaB p105/p50 (Ser893) Blocking Peptide
MBS9615574-5x1mg	MyBiosource	5x1mg	EUR 1650

Phospho-NF kappaB p105/p50 (Ser907) Blocking Peptide
MBS9615575-1mg	MyBiosource	1mg	EUR 380

Phospho-NF kappaB p105/p50 (Ser907) Blocking Peptide
MBS9615575-5x1mg	MyBiosource	5x1mg	EUR 1650

Phospho-NF kappaB p105/p50 (Ser903) Blocking Peptide
MBS9618976-1mg	MyBiosource	1mg	EUR 380

Phospho-NF kappaB p105/p50 (Ser903) Blocking Peptide
MBS9618976-5x1mg	MyBiosource	5x1mg	EUR 1650

Phospho-NF kappaB p105/p50 (Ser923) Blocking Peptide
MBS9618977-1mg	MyBiosource	1mg	EUR 380

Phospho-NF kappaB p105/p50 (Ser923) Blocking Peptide
MBS9618977-5x1mg	MyBiosource	5x1mg	EUR 1650

Anti-NF-kappaB p105/p50 Antibody
MBS8242205-003mL	MyBiosource	0.03mL	EUR 185

Anti-NF-kappaB p105/p50 Antibody
MBS8242205-01mL	MyBiosource	0.1mL	EUR 255

Anti-NF-kappaB p105/p50 Antibody
MBS8242205-02mL	MyBiosource	0.2mL	EUR 335

Anti-NF-kappaB p105/p50 Antibody
MBS8242205-5x02mL	MyBiosource	5x0.2mL	EUR 1420

Anti-NF-kappaB p105/p50 Antibody
MBS821663-003mL	MyBiosource	0.03mL	EUR 185

Anti-NF-kappaB p105/p50 Antibody
MBS821663-01mL	MyBiosource	0.1mL	EUR 255

Anti-NF-kappaB p105/p50 Antibody
MBS821663-02mL	MyBiosource	0.2mL	EUR 335

Anti-NF-kappaB p105/p50 Antibody
MBS821663-5x02mL	MyBiosource	5x0.2mL	EUR 1420

Anti-NF-kappaB p105/p50 Antibody
MBS9240063-01mL	MyBiosource	0.1mL	EUR 415

Anti-NF-kappaB p105/p50 Antibody
MBS9240063-5x01mL	MyBiosource	5x0.1mL	EUR 1841

NF-kappaB p105/p50 Antibody
E18-6217-1	EnoGene	50μg/50μl	EUR 145
Description: Available in various conjugation types.

NF-kappaB p105/p50 Antibody
E18-6217-2	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

NF-kappaB p105/p50 Antibody
E38PA4479	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

NF-kappaB p105/p50 Antibody
MBS8582538-01mL	MyBiosource	0.1mL	EUR 305

NF-kappaB p105/p50 Antibody
MBS8582538-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8582538-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8582538-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8582538-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8509482-01mg	MyBiosource	0.1mg	EUR 305

NF-kappaB p105/p50 Antibody
MBS8509482-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8509482-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8509482-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8509482-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8512277-005mg	MyBiosource	0.05mg	EUR 235

NF-kappaB p105/p50 Antibody
MBS8512277-01mg	MyBiosource	0.1mg	EUR 305

NF-kappaB p105/p50 Antibody
MBS8512277-01mLAF405M	MyBiosource	0.1mL(AF405M)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8512277-01mLAF546	MyBiosource	0.1mL(AF546)	EUR 465

NF-kappaB p105/p50 Antibody
MBS8512277-01mLAF750	MyBiosource	0.1mL(AF750)	EUR 465

NF-kappaB p105/p50 Antibody
MBS9601818-01mL	MyBiosource	0.1mL	EUR 260

NF-kappaB p105/p50 Antibody
MBS9601818-02mL	MyBiosource	0.2mL	EUR 305

NF-kappaB p105/p50 Antibody
MBS9601818-5x02mL	MyBiosource	5x0.2mL	EUR 1220

NF-kappaB p105/p50 Antibody
MBS9434990-005mL	MyBiosource	0.05mL	EUR 325

Thus, a common haplotype RETN tightly regulated by epigenetic mechanisms associated with p50 / p50-binding. This control is missing in the Asian haplotypes, which may have evolved to balance antagonistic effects on the protection RETN pathogen induction vs metabolism and inflammatory diseases.