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DOMESTIC SERUM & PLASMA

Acidic glycosaminoglycans (GAGs) were isolated from the serum and/or plasma of some domestic animals and the composition of the isolated GAG mixtures was studied. Mean values ​​of total GAG concentration, in terms of hexuronic acid, ranged from a maximum of approximately 12 mg / l in serum of calves, trained horses, and sheep to approximately 9 mg / l in serum of cows and donkeys and in plasma. of trained horses. up to approximately 6.5 mg / l in sedentary horse serum and rabbit plasma to a minimum of 4 mg / l in dog serum and sedentary horse plasma.

Statistically significant differences were found in total GAG concentrations (P <0.0005) in horses between plasma and serum and also between sedentary and trained subjects. Chondroitin sulfate was the main component in the GAG ​​mixtures in serum and plasma, representing 81 to 84% of the total GAG in the animals examined, except in cow serum (72%), horse plasma trained (75.5%), and sheep serum (87%).

Structures similar to keratan sulfate, measured as galactose, ranged from 12% in sheep serum to 17% in cattle serum. Fucose was associated with galactose in the GAG ​​fractions, supporting the hypothesis that articular cartilage is among the sites of origin of circulating GAGs.

Sarah

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