Tag: reagents sds

  • Thermally Targeted p50 Peptide Inhibits Proliferation and Induces Apoptosis of Breast Cancer Cell Lines

    Thermally Targeted p50 Peptide Inhibits Proliferation and Induces Apoptosis of Breast Cancer Cell Lines

    The application of peptides rationally designed therapy (TP) can improve the outcome of cancer treatment. This peptide hold the potential to directly target and stimulate proliferation pathways arrest or cell death pathways. Elastin like polypeptide (ELP) is a biopolymer derived elastin which undergoes a phase transition thermal mediated.

    This study using p50, a nuclear localization sequence derived peptide that inhibits the activation of NF and is involved in cancer cell survival and metastasis. In order to effectively delivery of p50, the conjugation SynB1-ELP1, thermally responsive macromolecular carrier. By applying an external heat source, lightly Hyperthermic conditions (41 ° C) to induce aggregation and therefore can be used to specifically target the ELP for solid tumors in cancer therapy.

    The addition of cell penetrating peptides (the CPP) with the N-terminus of the carrier macromolecule improving cellular uptake and direct the subcellular localization of bioactive peptides. Novel TP, p50, inhibit proliferation and induce apoptosis of breast cancer cells by blocking imports of intranuclear NF. By expanding the repertoire of oncogenic targets, CPP, and the size of the ELP carrier, based on ELP polypeptide may be modulated to optimize the delivery of new therapies and allow for flexibility to create individualized cancer therapy.

    Thermally Targeted p50 Peptide Inhibits Proliferation and Induces Apoptosis of Breast Cancer Cell Lines
    Thermally Targeted p50 Peptide Inhibits Proliferation and Induces Apoptosis of Breast Cancer Cell Lines

    Upregulation of miR-133a-3p in the sciatic nerve Contribute to Development of Neuropathic Pain

    Micro (mi) RNAs expressed in the sciatic nerve of streptozotocin (STZ) -induced diabetic rats were evaluated in terms of potential therapies in patients with diabetic neuropathic pain (DNP). Relative miRNA expression in the sciatic nerve with DNP analyzed using next-generation sequencing and quantitative PCR. potential downstream target miRNAs allegedly using Ingenuity Pathway Analysis and TargetScan database.

    In vitro experiments were performed using Schwann cells RSC96 miR-133a-3p-transfected. We do blotting and immunofluorescence analysis of micro-West and West to verify the role of miR-133a-3p. In vivo, the relationship between miR-133a-3p with DNP analyzed through AAV-miR-133a-3p intraneural (intra-epineural but extrafascicular) injection into the sciatic nerve of normal mice or injection of miR-133a-3p antagomir to the sciatic nerve of diabetes mellitus ( DM) rats.

    miR-133a-3p mimics transfected into Schwann cells RSC96 increased VEGFR-2, p38α MAPK, TRAF-6, and the expression of p50 NF PIAS3 and reduce MKP3 and expression. In normal rats, AAV-miR-133a-3p delivery through intraneural injection into sciatic nerve induced mechanical allodynia and p-p38 MAPK activation. At DM rats, administration of miR-133a-3p antagomir alleviated DNP and downregulated p-p38 phosphorylation. Overexpression of miR-133a-3p on the pain induced by sciatic nerve. We suggest that miR-133a-3p is a potential therapeutic target for DNP.


    Immunoregulatory effects and mechanisms of immunological response of Craterellus cornucopioides (L.) Pers. polysaccharides (CCP) with a triple-helix structure in peritoneal macrophages was investigated in vitro for the first time. This study showed that treatment of peritoneal macrophages with 80 ug / mL PKC for 48 hours significantly strengthen their phagocytic function and increased activity of lysozyme (LZM), acid phosphatase (ACP) and succinodehydrogenase (SDH) when compared to the untreated group.

    NFKB Repressing Factor (NKRF) Antibody

    20-abx003678
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    • 20 ul
    • 50 ul
    • 100 ul
    • 200 ul

    NFKB Repressing Factor (NKRF) Antibody

    abx003678-20l 20 µl
    EUR 175

    NFKB Repressing Factor (NKRF) Antibody

    abx003678-50l 50 µl
    EUR 275

    NFKB Repressing Factor (NKRF) Antibody

    abx129198-100l 100 µl
    EUR 275

    NFKB Repressing Factor (NKRF) Antibody

    20-abx129198
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    • 10 ug
    • 50 ug
    • 100 ug
    • 200 ug
    • 1 mg

    NFKB Repressing Factor (NKRF) Antibody

    abx129198-1ml 1 ml
    EUR 750

    NFKB Repressing Factor (NKRF) Antibody

    abx129198-200l 200 µl
    EUR 337.5

    NFKB Repressing Factor (NKRF) Antibody

    abx032921-400l 400 µl
    EUR 518.75

    NFKB Repressing Factor (NKRF) Antibody

    abx032921-400ul 400 ul
    EUR 627.6

    NFKB Repressing Factor (NKRF) Antibody

    abx032921-80l 80 µl
    EUR 281.25

    NFKB Repressing Factor (NKRF) Antibody

    abx173820-100l 100 µl
    EUR 787.5

    NFKB Repressing Factor (NKRF) Antibody

    20-abx173820
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    • 200 ug
    • 1 mg

    NFKB Repressing Factor (NKRF) Antibody

    abx173820-1ml 1 ml Ask for price

    NFKB Repressing Factor (NKRF) Antibody

    abx173820-200l 200 µl Ask for price

    NFKB Repressing Factor (NKRF) Antibody

    20-abx217183
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    • 50 ug
    • 100 ug

    NFKB Repressing Factor (NKRF) Antibody

    abx235747-100g 100 µg
    EUR 350

    NFKB Repressing Factor (NKRF) Antibody

    abx235747-100ug 100 ug
    EUR 577.2

    NFKB Repressing Factor (NKRF) Antibody

    abx375384-96tests 96 tests
    EUR 337.5

    Recombinant NFKB Repressing Factor (NKRF)

    MBS2029422-001mg 0.01mg
    EUR 170

    Recombinant NFKB Repressing Factor (NKRF)

    MBS2029422-005mg 0.05mg
    EUR 300

    Recombinant NFKB Repressing Factor (NKRF)

    MBS2029422-01mg 0.1mg
    EUR 450

    Recombinant NFKB Repressing Factor (NKRF)

    MBS2029422-02mg 0.2mg
    EUR 550

    Recombinant NFKB Repressing Factor (NKRF)

    MBS2029422-05mg 0.5mg
    EUR 1050

    Recombinant NFKB Repressing Factor (NKRF)

    RPU52738-100ug 100ug
    EUR 530.2

    Recombinant NFKB Repressing Factor (NKRF)

    RPU52738-1mg 1mg
    EUR 2347.8

    Recombinant NFKB Repressing Factor (NKRF)

    RPU52738-50ug 50ug
    EUR 425.7

    Recombinant NFKB Repressing Factor (NKRF)

    RPH536Hu01 10ug
    EUR 172

    Recombinant NFKB Repressing Factor (NKRF)

    4-RPH536Hu01
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    • 5 mg
    • 10ug
    • 50ug
    • 100 ug
    • 200 ug
    • 500 ug
    • 1 mg
    Description: Recombinant Human NFKB Repressing Factor expressed in: E.coli

    NFKB Repressing Factor (NKRF) Antibody Pair

    abx117615-1pair5x96wellplates 1 pair (5×96 well plates)
    EUR 1212

    Rat NFKB Repressing Factor ELISA Kit

    MBS054832-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Rat NFKB Repressing Factor ELISA Kit

    MBS054832-48StripWells 48-Strip-Wells
    EUR 550

    Rat NFKB Repressing Factor ELISA Kit

    MBS054832-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Rat NFKB Repressing Factor ELISA Kit

    MBS054832-96StripWells 96-Strip-Wells
    EUR 765

    Cat NFKB Repressing Factor ELISA Kit

    MBS063631-INQUIRE INQUIRE Ask for price

    Cavy NFKB Repressing Factor ELISA Kit

    MBS098510-INQUIRE INQUIRE Ask for price

    Duck NFKB Repressing Factor ELISA Kit

    MBS089665-INQUIRE INQUIRE Ask for price

    Goat NFKB Repressing Factor ELISA Kit

    MBS069739-INQUIRE INQUIRE Ask for price

    Fish NFKB Repressing Factor ELISA Kit

    MBS094699-INQUIRE INQUIRE Ask for price

    NFkB Repressing Factor (NKRF, ITBA4, NRF)

    MBS603882-01mg 0.1mg
    EUR 680

    NFkB Repressing Factor (NKRF, ITBA4, NRF)

    MBS603882-5x01mg 5×0.1mg
    EUR 2910

    Horse NFKB Repressing Factor ELISA Kit

    MBS100559-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Horse NFKB Repressing Factor ELISA Kit

    MBS100559-48StripWells 48-Strip-Wells
    EUR 550

    Horse NFKB Repressing Factor ELISA Kit

    MBS100559-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Horse NFKB Repressing Factor ELISA Kit

    MBS100559-96StripWells 96-Strip-Wells
    EUR 765

    Human NFKB Repressing Factor ELISA Kit

    MBS098823-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Human NFKB Repressing Factor ELISA Kit

    MBS098823-48StripWells 48-Strip-Wells
    EUR 550

    Human NFKB Repressing Factor ELISA Kit

    MBS098823-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Human NFKB Repressing Factor ELISA Kit

    MBS098823-96StripWells 96-Strip-Wells
    EUR 765

    Human NFKB Repressing Factor ELISA Kit

    IHUNKRFKT each
    EUR 733
    Description: Human NFKB Repressing Factor ELISA Kit

    Goose NFKB Repressing Factor ELISA Kit

    MBS072830-INQUIRE INQUIRE Ask for price

    Camel NFKB Repressing Factor ELISA Kit

    MBS095690-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Camel NFKB Repressing Factor ELISA Kit

    MBS095690-48StripWells 48-Strip-Wells
    EUR 550

    Camel NFKB Repressing Factor ELISA Kit

    MBS095690-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Camel NFKB Repressing Factor ELISA Kit

    MBS095690-96StripWells 96-Strip-Wells
    EUR 765

    Mouse NFKB Repressing Factor ELISA Kit

    MBS095697-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Mouse NFKB Repressing Factor ELISA Kit

    MBS095697-48StripWells 48-Strip-Wells
    EUR 550

    Mouse NFKB Repressing Factor ELISA Kit

    MBS095697-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Mouse NFKB Repressing Factor ELISA Kit

    MBS095697-96StripWells 96-Strip-Wells
    EUR 765

    Sheep NFKB Repressing Factor ELISA Kit

    MBS053424-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Sheep NFKB Repressing Factor ELISA Kit

    MBS053424-48StripWells 48-Strip-Wells
    EUR 550

    Sheep NFKB Repressing Factor ELISA Kit

    MBS053424-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Sheep NFKB Repressing Factor ELISA Kit

    MBS053424-96StripWells 96-Strip-Wells
    EUR 765

    Rabbit NFKB Repressing Factor ELISA Kit

    MBS066564-INQUIRE INQUIRE Ask for price

    Pigeon NFKB Repressing Factor ELISA Kit

    MBS105598-INQUIRE INQUIRE Ask for price

    Monkey NFKB Repressing Factor ELISA Kit

    MBS105080-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Monkey NFKB Repressing Factor ELISA Kit

    MBS105080-48StripWells 48-Strip-Wells
    EUR 550

    Monkey NFKB Repressing Factor ELISA Kit

    MBS105080-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Monkey NFKB Repressing Factor ELISA Kit

    MBS105080-96StripWells 96-Strip-Wells
    EUR 765

    Canine NFKB Repressing Factor ELISA Kit

    MBS049056-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Canine NFKB Repressing Factor ELISA Kit

    MBS049056-48StripWells 48-Strip-Wells
    EUR 550

    Canine NFKB Repressing Factor ELISA Kit

    MBS049056-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Canine NFKB Repressing Factor ELISA Kit

    MBS049056-96StripWells 96-Strip-Wells
    EUR 765

    Bovine NFKB Repressing Factor ELISA Kit

    MBS093832-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Bovine NFKB Repressing Factor ELISA Kit

    MBS093832-48StripWells 48-Strip-Wells
    EUR 550

    Bovine NFKB Repressing Factor ELISA Kit

    MBS093832-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Bovine NFKB Repressing Factor ELISA Kit

    MBS093832-96StripWells 96-Strip-Wells
    EUR 765

    NFKB Repressing Factor (NKRF) Polyclonal Antibody

    CAU21944-100ul 100ul
    EUR 235.2

    NFKB Repressing Factor (NKRF) Polyclonal Antibody

    CAU21944-200ul 200ul
    EUR 294

    Porcine NFKB Repressing Factor ELISA Kit

    MBS063663-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Porcine NFKB Repressing Factor ELISA Kit

    MBS063663-48StripWells 48-Strip-Wells
    EUR 550

    Porcine NFKB Repressing Factor ELISA Kit

    MBS063663-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Porcine NFKB Repressing Factor ELISA Kit

    MBS063663-96StripWells 96-Strip-Wells
    EUR 765

    Chicken NFKB Repressing Factor ELISA Kit

    MBS064399-INQUIRE INQUIRE Ask for price

    Hamster NFKB Repressing Factor ELISA Kit

    MBS054670-10x96StripWells 10×96-Strip-Wells
    EUR 6725

    Hamster NFKB Repressing Factor ELISA Kit

    MBS054670-48StripWells 48-Strip-Wells
    EUR 550

    Hamster NFKB Repressing Factor ELISA Kit

    MBS054670-5x96StripWells 5×96-Strip-Wells
    EUR 3420

    Hamster NFKB Repressing Factor ELISA Kit

    MBS054670-96StripWells 96-Strip-Wells
    EUR 765

    Human NFKB Repressing Factor (NKRF) Protein

    20-abx168193
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    • 10 ug
    • 50 ug
    • 100 ug
    • 200 ug
    • 1 mg

    Human NFKB Repressing Factor (NKRF) Protein

    abx168193-1ml 1 ml
    EUR 225

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (AP)

    MBS6429147-01mL 0.1mL
    EUR 950

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (AP)

    MBS6429147-5x01mL 5×0.1mL
    EUR 4120

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (PE)

    MBS6429157-01mL 0.1mL
    EUR 950

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (PE)

    MBS6429157-5x01mL 5×0.1mL
    EUR 4120

    Rabbit anti-human NFKB repressing factor polyclonal Antibody

    MBS713147-01mL 0.1mL
    EUR 485

    Rabbit anti-human NFKB repressing factor polyclonal Antibody

    MBS713147-5x01mL 5×0.1mL
    EUR 2175

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (APC)

    MBS6429148-01mL 0.1mL
    EUR 950

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (APC)

    MBS6429148-5x01mL 5×0.1mL
    EUR 4120

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (HRP)

    MBS6429151-01mL 0.1mL
    EUR 950

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (HRP)

    MBS6429151-5x01mL 5×0.1mL
    EUR 4120

    ELISA Kit for NFKB Repressing Factor (NKRF)

    SEH536Hu 96Т
    EUR 700

    Human NFKB Repressing Factor (NKRF) CLIA Kit

    20-abx495466
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    • 96 tests
    • 5 × 96 tests
    • 10 × 96 tests

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (FITC)

    MBS6429150-01mL 0.1mL
    EUR 950

    NKRF (NFkB Repressing Factor, NRF, ITBA4) (FITC)

    MBS6429150-5x01mL 5×0.1mL
    EUR 4120

    Polyclonal Antibody to NFKB Repressing Factor (NKRF)

    MBS2027042-01mL 0.1mL
    EUR 175

    Polyclonal Antibody to NFKB Repressing Factor (NKRF)

    MBS2027042-02mL 0.2mL
    EUR 220

    Polyclonal Antibody to NFKB Repressing Factor (NKRF)

    MBS2027042-05mL 0.5mL
    EUR 355

    Polyclonal Antibody to NFKB Repressing Factor (NKRF)

    MBS2027042-1mL 1mL
    EUR 435

    Polyclonal Antibody to NFKB Repressing Factor (NKRF)

    MBS2027042-5mL 5mL
    EUR 1185

    Polyclonal Antibody to NFKB Repressing Factor (NKRF)

    PAH536Hu01 100ul
    EUR 245

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    20-abx152530
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    • 96 tests
    • 5 × 96 tests
    • 10 × 96 tests

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    DLR-NKRF-Hu 96T
    EUR 463
    Description: tissue homogenates or other biological fluids.

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    DLR-NKRF-Hu-48T 48T
    EUR 620.4
    Description: A sandwich quantitative ELISA assay kit for detection of Human NFKB Repressing Factor (NKRF) in samples from tissue homogenates or other biological fluids.

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    DLR-NKRF-Hu-96T 96T
    EUR 807.6
    Description: A sandwich quantitative ELISA assay kit for detection of Human NFKB Repressing Factor (NKRF) in samples from tissue homogenates or other biological fluids.

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    DL-NKRF-Hu 96T
    EUR 441
    Description: tissue homogenates or other biological fluids.

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    EKU06290-48T 48T
    EUR 555.66

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    EKU06290-5x96T 5x96T
    EUR 3770.55

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    EKU06290-96T 96T
    EUR 793.8

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    EK15740 96Т
    EUR 768

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    EKN47401-48T 48T
    EUR 378.7

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    EKN47401-5x96T 5x96T
    EUR 2569.75

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    EKN47401-96T 96T
    EUR 541

    Human NFKB Repressing Factor,NKRF ELISA KIT

    E3506Hu-1096T 10*96T
    EUR 4122

    Human NFKB Repressing Factor,NKRF ELISA KIT

    E3506Hu-48wells 48 wells
    EUR 300

    Human NFKB Repressing Factor,NKRF ELISA KIT

    E3506Hu-596T 5*96T
    EUR 2061

    Human NFKB Repressing Factor,NKRF ELISA KIT

    E3506Hu-96wells 96 wells
    EUR 458

    Human NFKB Repressing Factor,NKRF ELISA KIT

    JOT-EK3506Hu 96 wells Ask for price
    Description: Human

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS4501385-10x96Tests 10x96Tests
    EUR 5260

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS4501385-48Tests 48Tests
    EUR 460

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS4501385-5x96Tests 5x96Tests
    EUR 2700

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS4501385-96Test 96Test
    EUR 605

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS452449-10x96StripWells 10×96-Strip-Wells
    EUR 5050

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS452449-48StripWells 48-Strip-Wells
    EUR 440

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS452449-5x96StripWells 5×96-Strip-Wells
    EUR 2590

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS452449-96StripWells 96-Strip-Wells
    EUR 585

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS2706412-10x96StripWells 10×96-Strip-Wells
    EUR 3130

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS2706412-24StripWells 24-Strip-Wells
    EUR 255

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS2706412-48StripWells 48-Strip-Wells
    EUR 330

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS2706412-5x96StripWells 5×96-Strip-Wells
    EUR 1630

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS2706412-96StripWells 96-Strip-Wells
    EUR 420

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS166852-10x96StripWells 10×96-Strip-Wells
    EUR 3460

    Human NFKB Repressing Factor (NKRF) ELISA Kit

    MBS166852-48StripWells 48-Strip-Wells
    EUR 285

    Furthermore, Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) assay showed that 80 ug / mL PKC activated macrophages, significantly increased the mRNA expression of cytokines (IL-8, IL-1β, IFN-α and TNF-α ) and upregulated the expression of TLR4 cell membrane receptor protein, and protein kinase downstream product (MyD88, TAK1, P-IKKα / β, and P-MEK) via activation of TLR4-NF in peritoneal macrophages.