Transcription factor NF has been associated with the timing of menopause in human genome-wide association studies were great. Additionally, preclinical studies indicate that the loss of tumor necrosis factor alpha (TNF) or receptor activation Tnfr2 slow the growth of primordial follicles (PFGA). Although TNFa: receptor signaling stimulates the NF and may mechanically connect these findings, very little is known about the signal NF PFGA.
Because the downstream signal TNFa / Tnfr2 ligand / receptor interactions has not been questioned as pertaining to PFGA, we evaluated the expression of key proteins in the signal NF and growing primordial follicles, as well as during the aging ovaries. We show that the key members of the pathway NF, including subunit, activating kinase and inhibitory proteins, expressed in murine ovary. In addition, the p65 and p50 subunits, and cytosolic inhibitory protein IκBα and IκBβ, which is present in the ovarian follicle, including the primordial stage. Finally, we assess PFGA in mice genetically modified (AKBI) previously shown to be resistant to stress-induced inflammatory activation of NF because of excessive inhibition of protein NF IκBβ.
Consistent with the hypothesis that NF play a key role in PFGA, rats showed slower AKBI PGFA from the wild type (WT) control, and their ovaries contain nearly twice the number of primordial follicles as WT good at the beginning and end of reproductive age. These data provide mechanistic insights on the control of PFGA and suggest that targeting NF on IκB protein level may be obedient to slow the pace of these PFGA in women faced with the early death of the ovaries.
Control of Murine Primordial Follicle Growth Activation by IκB/NFκB Signaling
Effects of Granulocyte Macrophage Colony-Stimulating Factor Inhibition of skin / nerve Cells In Vitro Model
The study was based on the concept of neuro-aging and how it can affect the surrounding skin cells. It has been proven that a lot of factors that play an important role in the homeostasis of the skin by interfering with various cytokines, either through activation or inhibition. Granulocyte macrophage colony-stimulating factor (GM-CSF) is generally recognized as an inflammatory cytokine, and our previous research has shown its effects on neuronal aging after ultraviolet (UV) irradiation of skin cells.
Following our previous work, this study was conducted to investigate the neuroprotective effects of GM-CSF antagonist, and how it may play an important role in mediating the anti-aging and anti-inflammatory effects in keratinocytes models / neural aging. When the cells were blastoma man (SH-SY5Y) were treated with 10 ng / ml GM-CSF, RNA level rules associated with aging, such as matrix metalloproteinase-9 (MMP9), nuclear factor NF-kappa-B p50 subunit (NFkB) , inducible nitric oxide synthase (iNOS) and interleukin 1 beta (IL-1β) increased, whereas GM-CSF inhibition causes decreased their expression.
The decline in the antioxidant, glutathione (GSH) was observed after the SH-SY5Y cells treated with GM-CSF. This study confirms that the GM-CSF antagonist may play an important role in the aging of nerves, in which inhibition may be a new target in the skin / nerve aging model.Erinacine A, which is one of the major diterpenoid bioactive compounds extracted from cultured mycelia of H. erinaceus, featuring great antitumorigenic activity.
TANK TRAF Family Member-Associated NFKB Activator Human Recombinant Protein
Description: TANK produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids (1-119 a.a.) and having a molecular mass of 13.6 kDa.;TANK is purified by proprietary chromatographic techniques.
TANK TRAF Family Member-Associated NFKB Activator Human Recombinant Protein
Description: TANK Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 448 amino acids (1-425a.a) and having a molecular mass of 50.2kDa. TANK is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TRAF Family Member Associated NFKB Activator (TANK) Polyclonal Antibody (Human, Pig)
Description: A Rabbit polyclonal antibody against Human, Pig TRAF Family Member Associated NFKB Activator (TANK). This antibody is labeled with Biotin.
TRAF Family Member Associated NFKB Activator (TANK) Polyclonal Antibody (Human, Pig), Cy3
Description: A Rabbit polyclonal antibody against Human, Pig TRAF Family Member Associated NFKB Activator (TANK). This antibody is labeled with APC-Cy7.
TRAF Family Member-Associated NF-Kappa-B Activator (TANK) Antibody
Description: Quantitative sandwich ELISA for measuring Mouse TRAF family member-associated NF-kappa-B activator (TANK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Mouse TRAF family member-associated NF-kappa-B activator (TANK)
Description: Quantitative sandwich ELISA for measuring Mouse TRAF family member-associated NF-kappa-B activator (TANK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Mouse TRAF family member-associated NF-kappa-B activator (TANK)
Description: Quantitative sandwich ELISA for measuring Mouse TRAF family member-associated NF-kappa-B activator (TANK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human TRAF family member-associated NF-kappa-B activator (TANK)
Description: Quantitative sandwich ELISA for measuring Human TRAF family member-associated NF-kappa-B activator (TANK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human TRAF family member-associated NF-kappa-B activator (TANK)
Description: Quantitative sandwich ELISA for measuring Human TRAF family member-associated NF-kappa-B activator (TANK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human TRAF family member-associated NF-kappa-B activator (TANK)
Description: Quantitative sandwich ELISA for measuring Human TRAF family member-associated NF-kappa-B activator (TANK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Tank ELISA Kit| Mouse TRAF family member-associated NF-kappa-B
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Nuclear Factor Kappa B (NFkB) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Nuclear Factor Kappa B (NFkB) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Nuclear Factor Kappa B (NFkB) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Nuclear Factor Kappa B (NFkB) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Nuclear Factor Kappa B (NFkB) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Nuclear Factor Kappa B (NFkB) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Nuclear Factor Kappa B (NFkB) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Nuclear Factor Kappa B (NFkB) in samples from tissue homogenates, cell lysates or other biological fluids.
However, the molecular mechanisms underlying erinacine A induces cancer cell apoptosis in colorectal cancer (CRC) remains unclear. The study found that treatment with erinacine A not only triggers the activation of the extrinsic apoptotic pathway (TNFR, Fas, FasL, and caspases) but also suppress the expression of antiapoptotic molecule Bcl-2 and Bcl-XL through a time-dependent manner in DLD -1 cells.
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Antibodies | Assay Kits | Biology Cells | cDNA | Clia Kits | Culture Cells | Devices | DNA | DNA Templates | DNA Testing | Elisa Kits | Enzymes | Equipments | Exosomes | Gels | Isotypes | Medium & Serums | NATtrol | Panel | Particles | PCR | Pcr Kits | Peptides | Reagents | Recombinant Proteins | Ria Kits | RNA | Test Kits | Uncategorized | Vector & Virus | Western Blot 
Antibodies | Assay Kits | Biology Cells | cDNA | Clia Kits | Culture Cells | Devices | DNA | DNA Templates | DNA Testing | Elisa Kits | Enzymes | Equipments | Exosomes | Gels | Isotypes | Medium & Serums | NATtrol | Panel | Particles | PCR | Pcr Kits | Peptides | Reagents | Recombinant Proteins | Ria Kits | RNA | Test Kits | Uncategorized | Vector & Virus | Western Blot
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